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Machine Learning Street Talk / episode intelligence

He won a Nobel here for AlphaFold. Then he left. - John Jumper

22 Jun 2026 10 published claims 1 attributable person

Speakers in the public record

Claim mix

evaluation 3belief 2preference 2prediction 2commitment 1

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10 published records

02 / evaluation

I mean, AlphaFold itself is this kind of, I guess, I now say landmark in AI and science, but it's really about how do we use AI to solve problems that humans can't, that are really hard, that we go and we do years long experiments.

“I mean, AlphaFold itself is this kind of, I guess, I now say landmark in AI and science, but it's really about how do we use AI to solve problems that humans can't, that are really hard, that we go and we do years long experiments.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

03 / preference

But after AlphaFold 1 and then kind of all the protein specific bits were kind of wrapped around the machine learning. And so the I would say alpha fold 2 was, let's build the science instead of building the science of image recognition and then applying it to proteins because, you know, human visual the human visual system is exactly what we needed to fold proteins is not something true.

“But after AlphaFold 1 and then kind of all the protein specific bits were kind of wrapped around the machine learning. And so the I would say alpha fold 2 was, let's build the science instead of building the science of image recognition and then applying it to proteins because, you know, human visual the human visual system is exactly what we needed to fold proteins is not something true.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

04 / preference

In my own research on on drug discovery, so I use Alpha 4 in terms of solving structures of cryo EM data, and I also utilize that to to to map out the mechanisms of the proteins.

“In my own research on on drug discovery, so I use Alpha 4 in terms of solving structures of cryo EM data, and I also utilize that to to to map out the mechanisms of the proteins.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

06 / belief

I think AlphaFold 3 diffusion is similar, and it's especially similar because, in fact, in images, okay, you start generating an image and you see especially these early trained diffusion models generate kind of colored blobs, and they start to decide what those colored blobs mean.

“I think AlphaFold 3 diffusion is similar, and it's especially similar because, in fact, in images, okay, you start generating an image and you see especially these early trained diffusion models generate kind of colored blobs, and they start to decide what those colored blobs mean.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

07 / prediction

We predict nature level science with the press of a button in a very narrow category of nature level science of the structure of a specific protein.

“We predict nature level science with the press of a button in a very narrow category of nature level science of the structure of a specific protein.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

08 / commitment

We are a predictor of this experiment that you did all the time and took you a year. And so in a certain sense, I think and so we have validity in that I can characterize very well how well we're we we will reproduce that experiment.

“We are a predictor of this experiment that you did all the time and took you a year. And so in a certain sense, I think and so we have validity in that I can characterize very well how well we're we we will reproduce that experiment.”
Speaker
Not verified from transcript
Publisher
Machine Learning Street Talk

09 / evaluation

Even that, I think you can argue, maybe not entirely the story, but it's definitely not the story for proteins because that's the hardest problem is the large scale structure.

“Even that, I think you can argue, maybe not entirely the story, but it's definitely not the story for proteins because that's the hardest problem is the large scale structure.”
Speaker
Tim Scarfe
Publisher
Machine Learning Street Talk

10 / prediction

There are now structural biologists around the world that can innovate and build new products and save lives potentially because they have access to this protein database.

“There are now structural biologists around the world that can innovate and build new products and save lives potentially because they have access to this protein database.”
Speaker
Tim Scarfe
Publisher
Machine Learning Street Talk
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