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🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

12 Feb 2026 11 published claims 0 attributable people

Speakers in the public record

Claim mix

belief 8evaluation 1prediction 1commitment 1

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11 published records

02 / belief

You know, as we mentioned, like I think at the very beginning is the goal with the product has been to, you know, address what the models don’t on their own.

“You know, as we mentioned, like I think at the very beginning is the goal with the product has been to, you know, address what the models don’t on their own.”
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Latent Space

03 / belief

General pattern, I think, in like in trying to design things that are smaller, you know, like it’s easier to manufacture at the same time, like that comes with like potentially other challenges, like maybe a little bit less selectivity than like if you have something that has like more hands, you know, but the yeah, there’s this big desire to, you know, try to design many proteins, nanobodies, small peptides, you know, that just are just great drug modalities.

“General pattern, I think, in like in trying to design things that are smaller, you know, like it’s easier to manufacture at the same time, like that comes with like potentially other challenges, like maybe a little bit less selectivity than like if you have something that has like more hands, you know, but the yeah, there’s this big desire to, you know, try to design many proteins, nanobodies, small peptides, you know, that just are just great drug modalities.”
Speaker
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Latent Space

04 / belief

In my opinion, all the people we basically talk about feel that this sort of like in the wet lab or whatever the appropriate, you know, sort of like in real world validation is the whole problem or not the whole problem, but a big giant part of the problem.

“In my opinion, all the people we basically talk about feel that this sort of like in the wet lab or whatever the appropriate, you know, sort of like in real world validation is the whole problem or not the whole problem, but a big giant part of the problem.”
Speaker
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Latent Space

05 / belief

The ranking model ends up finding something it really likes. And so I think our ability to get better at ranking, I think, is also what’s going to enable sort of the next, you know, next big, big breakthroughs.

“The ranking model ends up finding something it really likes. And so I think our ability to get better at ranking, I think, is also what’s going to enable sort of the next, you know, next big, big breakthroughs.”
Speaker
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Latent Space

06 / belief

You know, we have a Slack community that has like thousands of people on it. And it’s actually like self-sustaining now, which is like the really nice part because, you know, it’s, it’s almost overwhelming, I think, you know, to be able to like answer everyone’s questions and help.

“You know, we have a Slack community that has like thousands of people on it. And it’s actually like self-sustaining now, which is like the really nice part because, you know, it’s, it’s almost overwhelming, I think, you know, to be able to like answer everyone’s questions and help.”
Speaker
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Latent Space

07 / belief

On the other hand, kind of going to your question of, you know, why do we care about, you know, how the protein falls or, you know, how the car is made to some extent is that, you know, sometimes when something goes wrong, you know, there are, you know, cases of, you know, proteins misfolding.

“On the other hand, kind of going to your question of, you know, why do we care about, you know, how the protein falls or, you know, how the car is made to some extent is that, you know, sometimes when something goes wrong, you know, there are, you know, cases of, you know, proteins misfolding.”
Speaker
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Latent Space

08 / evaluation

And there’s a lot of like healthy skepticism in the field, which I think, you know, is, is, is great. And I think, you know, it’s very clear that there’s a ton of things, the models don’t really work well on, but I think one thing that’s probably, you know, undeniable is just like the pace of, pace of progress, you know, and how, how much better we’re getting, you know, every year.

“And there’s a lot of like healthy skepticism in the field, which I think, you know, is, is, is great. And I think, you know, it’s very clear that there’s a ton of things, the models don’t really work well on, but I think one thing that’s probably, you know, undeniable is just like the pace of, pace of progress, you know, and how, how much better we’re getting, you know, every year.”
Speaker
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Latent Space

09 / prediction

One thing I was thinking about with regards to infrastructure, like in the LLM space, you know, the cost of a token has gone down by I think a factor of a thousand or so over the last three years, right?

“One thing I was thinking about with regards to infrastructure, like in the LLM space, you know, the cost of a token has gone down by I think a factor of a thousand or so over the last three years, right?”
Speaker
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10 / belief

One of the critical kind of, you know, beliefs that we had, you know, also when we started working on Boltz 1 was sort of like the structure prediction models are somewhat, you know, our field version of some foundation models, you know, learning about kind of how proteins and other molecules interact.

“One of the critical kind of, you know, beliefs that we had, you know, also when we started working on Boltz 1 was sort of like the structure prediction models are somewhat, you know, our field version of some foundation models, you know, learning about kind of how proteins and other molecules interact.”
Speaker
Not verified from transcript
Publisher
Latent Space
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