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Jacob Kimmel

Published podcast speaker

Claims
19
Episodes
1
Shows
1
Named items
0

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What Jacob said.

6 transcript-backed records

01 / evaluation

Because mutations are going to be random and they're inherently small changes at the level of sequence at a given time, evolution needs a substrate where, in order to function effectively, these small changes can give you relatively large changes in phenotype.

“Because mutations are going to be random and they're inherently small changes at the level of sequence at a given time, evolution needs a substrate where, in order to function effectively, these small changes can give you relatively large changes in phenotype.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast

02 / evaluation

If you just look at the rank-ordered list of what are the most frequently expressed genes in the genome by the count of how many mRNAs are in the cell, transcription factors are near the bottom. That means you don't actually need to get that many copies of a transcription factor into a cell in order to have benefits.

“If you just look at the rank-ordered list of what are the most frequently expressed genes in the genome by the count of how many mRNAs are in the cell, transcription factors are near the bottom. That means you don't actually need to get that many copies of a transcription factor into a cell in order to have benefits.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast

03 / evaluation

I would say–I don't have formal way of explaining this–if you were to write out a list of well-known targets that many, many folks would agree are the correct genes to go after and to try and inhibit or activate in order to treat a given set of diseases—and the only reason we don't have medicines is that we can't figure out a trick in order to be able to drug them—it's a fairly small list.

“I would say–I don't have formal way of explaining this–if you were to write out a list of well-known targets that many, many folks would agree are the correct genes to go after and to try and inhibit or activate in order to treat a given set of diseases—and the only reason we don't have medicines is that we can't figure out a trick in order to be able to drug them—it's a fairly small list.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast

04 / evaluation

We're still differentiated because we do everything in human cells with the right number of chromosomes, whereas it's very common to do things in cancer cell lines which have 200 chromosomes.

“We're still differentiated because we do everything in human cells with the right number of chromosomes, whereas it's very common to do things in cancer cell lines which have 200 chromosomes.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast

05 / evaluation

If you take a selfish gene view of the world—that really this is the genome optimizing for the genome's propagation, it's not trying to optimize for any one individual—then actually optimizing for longevity is a pretty tricky problem because you have this nasty regularization term.

“If you take a selfish gene view of the world—that really this is the genome optimizing for the genome's propagation, it's not trying to optimize for any one individual—then actually optimizing for longevity is a pretty tricky problem because you have this nasty regularization term.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast

06 / evaluation

If these cells were not growing and they were not proliferating like mad, you probably would never be able to detect that you had actually found anything successful. It's only because success is easy to measure once you have it and—even being successful in very rare cases, one in a million—amplifies and you can detect it, that this was amenable to his particular approach.

“If these cells were not growing and they were not proliferating like mad, you probably would never be able to detect that you had actually found anything successful. It's only because success is easy to measure once you have it and—even being successful in very rare cases, one in a million—amplifies and you can detect it, that this was amenable to his particular approach.”
Speaker
Jacob Kimmel
Publisher
Dwarkesh Podcast
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