David Rosenthal: belief

Transcript context

…The mechanism by which it does this is totally fascinating. You mentioned that the fatty acid gets attached to the GLP-1 to create this GLP-1 analogue. The way it basically works is it has to bind in a very specific location, such that the receptor is not blocked, but it is grafted onto that molecule so they can travel together. The fatty acids then make it so the GLP-1 can bind to another protein, which I believe is pronounced albumin, which is this really large protein that is very common in the bloodstream. It protects the GLP 1 molecule from the degradation by enzymes, and it protects it from being quickly cleared in the kidney, because that bound molecule is now too complex, too large to be filtered. It makes it like a big truck bouncing down a small highway in that the molecule is protected. Yeah. I think that's how she phrases it too, when she describes it as protecting the molecule. Yup. The fatty acid makes it big and stick to stuff.…

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