Evidence receipt / belief
Published · transcript-backedBen Gilbert: belief
22 Jan 2024 Acquired Novo Nordisk (Ozempic)
“The fatty acids then make it so the GLP-1 can bind to another protein, which I believe is pronounced albumin, which is this really large protein that is very common in the bloodstream. It protects the GLP 1 molecule from the degradation by enzymes, and it protects it from being quickly cleared in the kidney, because that bound molecule is now too complex, too large to be filtered.”
Source trail
Everything needed to verify it.
- Speaker
- Ben Gilbert
- Attribution
- Verified speaker
- Claim type
- belief
- Recorded
- 22 Jan 2024
- Publisher
- Acquired
- Episode
- Novo Nordisk (Ozempic)
Transcript context
…Yeah. That satisfies management's ultimatum. The mechanism by which it does this is totally fascinating. You mentioned that the fatty acid gets attached to the GLP-1 to create this GLP-1 analogue. The way it basically works is it has to bind in a very specific location, such that the receptor is not blocked, but it is grafted onto that molecule so they can travel together. The fatty acids then make it so the GLP-1 can bind to another protein, which I believe is pronounced albumin, which is this really large protein that is very common in the bloodstream. It protects the GLP 1 molecule from the degradation by enzymes, and it protects it from being quickly cleared in the kidney, because that bound molecule is now too complex, too large to be filtered. It makes it like a big truck bouncing down a small highway in that the molecule is protected. Yeah. I think that's how she phrases it too, when she describes it as protecting the molecule.…
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