David Reich: prediction

Transcript context

…Interesting. We’ve been able to prove that there are two ways to reconcile the previous observations with our new observations. Remember, the previous observation is that natural selection seems to have been quiescent over a timescale of hundreds of thousands or many tens of thousands of years. Reason? That you don’t see 100% difference in frequency variance across Europeans and East Asians. Now we’re seeing hundreds of positions that are rocketing up in frequency with selection rates of 1% or more in a lot of cases. A 1% or more selection rate will mean a rapid doubling over periods of dozens of generations. Over the 1,500 or 2,000 generations separating Europeans and East Asians, shouldn’t you see many genetic variants that are 100% different in frequency across populations? We were able to show that this is explained by at least two factors. One is that in this part of the world—Europe and the Middle East—we are actually in a period of accelerated natural selection. One way to see this is to look at the enrichment pattern we’re observing, where immune traits are unusually associated with these selection signals. We could compare the last 5,000 years of our time period, what’s called the Bronze Age and further onward, to the previous 5,000 years. What we see is that this intensification of selection around immune traits, and similarly the intensification around metabolic traits, has accelerated over this time period. It’s not like natural selection has been at the same rate over all places and times. It’s increasing over the time period we’re analyzing. Plausibly the whole time period has increased compared to previous periods. We’re in a period of intensified selection. That’s not implausible, because this is a population that went through a huge shock in terms of the way people live and the culture. Almost everyone we’re analyzing are farmers or food producers in one way or another. Farming was invented for the first time anywhere in the world in the Middle East 11,000 or 12,000 years ago. The people who invented farming exploded into Europe after 8,500 years ago, spread across the continent, and expanded rapidly. In the Bronze Age, there was an intensification of how people lived, with much higher population densities. People were living more and more next to their animals and getting their diseases, and exchanging their diseases with the animals and with each other. This is a period of rapid change in how people are living, resulting in different biological needs of this population. It’s not surprising, perhaps, that in the context of these dramatic changes, the biology of the population might not be ideally adapted. There might be what some people call an evolutionary mismatch, where you take a genetic variation that evolved in hunter-gatherers and put it into farmers or pastoralists, and it’s not exactly right. There might be what some people call an evolutionary mismatch, where you take a genetic variation that evolved in hunter-gatherers and put it into farmers or pastoralists, and it’s not exactly right. What you’re seeing is the DNA of this population, which descended from hunter-gatherers only 10,000 years ago, reacting to the shock of having been moved into an agricultural, Bronze Age, high-population-density, urban environment. A hypothesis is that what we’re seeing is the adaptation that occurs as a result.…

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