David Reich: belief

Transcript context

…Interesting. What did you guys find? Seven years ago, Ali Akbari, who at the time was a postdoctoral scientist in my laboratory and a few years later became a permanent staff scientist, set out to use the data we were producing to learn about biological change over time. I think the reason he was interested in our laboratory rather than other places was that a focus of our lab has been generating truly large amounts of data from ancient humans. We’ve been trying to industrialize the process, make it very inexpensive, make it high quality, and generate large numbers of samples with lots of good data for this purpose. There’s been this large amount of data we’ve generated. And it made it possible to conceive again of asking whether there have been frequency changes over time. The mainstream view in human evolution in the last several decades has been that natural selection has been pretty quiescent over the last several hundred thousand years of human history. There are several lines of evidence that have been deployed to document this. One is that if you compare diverse populations from different continents around the world, for example Europeans and East Asians, and you look at mutations that differ in frequency between these groups—all mutations differ a little bit in frequency, sometimes a lot—you can say, “What are the most different mutations in terms of frequency between Europeans and East Asians?” And there are almost no genetic changes that are 100% different in frequency between Europeans and East Asians. Europeans and East Asians descend from a common ancestral population 40,000 or 50,000 years ago that came out of Africa and the Middle East. This population had a set of gene frequencies, and these variants bopped around randomly—a process known as genetic drift—or perhaps under selection in one direction or another. The time that’s passed since 40,000 or 50,000 years ago is sufficiently small on an evolutionary timescale that there’s just not much genetic differentiation on average between these two groups. However, if there’s been natural selection, for example to help people in one place digest alcohol better, or digest milk better, what you might expect is that there would be some mutation that would have rocketed up to very high frequency. Forty or fifty thousand years is a lot of time, it’s maybe 1,500-2,000 generations. That might easily be enough time to see a 100% difference in frequency. Yet you don’t see any more than what you would expect by chance. This combination of things made it seem that selection has just been quiescent. Maybe a few hundred thousand years ago, the ancestral human population got to some kind of optimum, and after that there hasn’t been much genetic change in one way or the other. There have been small amounts of natural selection, or selection to remove bad mutations that are constantly raining down on the genome, but not what we call directional selection. e way or the other. There have been small amounts of natural selection, or selection to remove bad mutations that are constantly raining down on the genome, but not what we call directional selection. That would be newly arising mutations, or mutations being pushed in a systematic direction, to help the population get to a different adaptive set point more favorable for the conditions that population is living in. We were able to partition how much of the changes in frequencies of all the mutations that we’re seeing in the DNA—we’re looking at about 10 million positions that vary—is due to directional selection (adaptation) versus other factors, especially genetic drift. And 98% of it is other factors, especially genetic drift. It’s overwhelmingly migrations and population structure causing fluctuations in frequency. As a result, it’s super hard to detect the signals of adaptive natural selection because they’re a tiny fraction of the total frequency change. The vast majority of it are these migrations and mixtures. Nevertheless, there’s so much natural selection, as our study has shown, that it’s actually been rampant in the genome.…

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