Andrew Huberman: evaluation

Transcript context

…Do you try to not just look at the science but research what the various communities are talking about? Like maybe research what the conspiracy theorists are talking about? Just so you know all the armies that are going to be attacking your castle. Yes. So for instance, there’s a community of people online that believe that if you consume seed oils or something, that you’re setting up your skin sunburn. And if you don’t… There’s all these theories. So I like to know what the theories are. I like to know what the extremes are but I also like to know what the standard conversation is. But there’s generally more agreement than disagreement. I think where I’ve been bullish actually is… Like supplements. People go, “Oh, supplement-“ Kind of bullish actually are supplements. People go, “Oh, supplements.” Well, there’s food supplements, like a protein powder, which is different than a vitamin, and then they are compounds. There are compounds that have real benefit, but people get very nervous about the fact that they’re not regulated, but some of them are vetted for potency and for safety with more rigor than others. And it’s interesting to see how people who take care of themselves and put a lot of work into that are often attacked. That’s been interesting. Also, one of the most controversial topics nowadays is Ozempic, Mounjaro. I’m very middle-of-the-road on this. I don’t understand why the “health wellness community” is so against these things. I also don’t understand why they have to be looked at as the only route. For some people, they’ve really helped them lose weight, and yes, there can be some muscle loss and other lean body loss, but that can be offset with resistance training. They’ve helped a lot of people. And other people are like, “No, this stuff is terrible.” I think the most interesting thing about Ozempic, Mounjaro is that they are GLP-1. They’re in the GLP-1 pathway, glucagon-like peptide-1, and it was discovered in Gila monsters, which is a lizard basically, and now the entomologists will dive on me. It’s a big lizard-looking thing that doesn’t eat very often, and they figured out that there’s this peptide that allows it to curb its own appetite at the level of the brain and the gut, and it has a lot of homology to, sequence homology, to what we now call GLP-1. So I love any time there’s animal biology links to cool human biology links to a drug that’s powerful that can help people with obesity and type 2 diabetes, and there’s evidence they can even curb some addictions. Those are newer data. But I don’t see it as an either/or. In fact, I’ve been a little bit disappointed at the way that the, whatever you want to call it, health wellness, biohacking community has slammed on Ozempic, Mounjaro. They’re like, “Just get out and run and do…” Listen, there are people who are carrying substantial amounts of weight that running could injure them. They get on these drugs and they can improve, and then hopefully they’re also doing resistance training and eating better, and then you’re bringing all the elements together. Well, why do you think the criticism is happening? Is it that Ozempic became super popular so people are misusing it or that kind of thing?…

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