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Published · transcript-backed

Adam Marblestone: belief

30 Dec 2025 Dwarkesh Podcast Adam Marblestone — AI is missing something fundamental about the brain

“I think there’s a lot of ways to do moonshot neuroscience companies that would never get you the connectome.”

— Adam Marblestone

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Speaker
Adam Marblestone
Attribution
Verified speaker
Claim type
belief
Recorded
30 Dec 2025
Publisher
Dwarkesh Podcast

Transcript context

…Also, there’s been many labs that have been launched in the last year where they’re raising on the valuation of billions for things which are quite credible but are not like, “Our ARR next quarter is going to be whatever.” It’s like we’re going to discover materials and— Yes, moonshot startups or billionaire-backed startups. Moonshot startups I see as on a continuum with FROs. FROs are a way of channeling philanthropic support and ensuring that it’s open source public benefit, various other things that may be properties of a given FRO. But yes, billionaire-backed startups, if they can target the right science, the exact right science. I think there’s a lot of ways to do moonshot neuroscience companies that would never get you the connectome. It’s like, “Oh, we’re going to upload the brain” or something, but never actually get the mouse connectome or something. These fundamental things that you need to get to ground truth the science. There are lots of ways to have a moonshot company go wrong and not do the actual science. But there also may be ways to have companies or big corporate labs get involved and actually do it correctly. This brings to mind an idea that you had in a lecture you gave five years ago about. Do you want to explain behavior cloning?…

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